1295568-45-4Relevant academic research and scientific papers
Total Syntheses of the 3 H-Pyrrolo[2,3- c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway
Banwell, Martin G.,Bolte, Benoit,Bryan, Christopher S.,Fraser, Nicholas J.,Jackson, Colin J.,Kendrick, Amy,Lan, Ping,Rihouey, Charly,Sayyahi, Soheil,Sharp, Phillip P.,Ward, Jas S.,Willis, Anthony C.
, (2019)
Compounds 1-6 and 11 representing key members of the marinoquinoline family of natural products, together with the related marine alkaloid aplidiopsamine A (12), have been synthesized using various combinations of palladium-catalyzed Ullmann cross-coupling and reductive cyclization processes involving a C3-arylated pyrrole as the common intermediate. These natural products have been characterized by single-crystal X-ray analyses and evaluated as inhibitors of acetylcholinesterase (AChE) with congener 2 proving to be the most active.
