1296137-68-2

Upstream product

• 674309-47-8 (1R,2R)-2-hydroxycyclohex-3-en-1-yl acetate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1296137-85-3 (1R,2R)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl acetate 
• 1296137-84-2 (1R,2R)-2-((tert-butyldimethylsilyl)oxy)cyclohex-3-en-1-yl acetate 
• 1296137-65-9 tert-butyl(((1R)-2-iodocyclohexyl)oxy)dimethylsilane 
• 364632-83-7 (1R,2R)-2-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol 

Relevant academic research and scientific papers

Highly diastereoselective iron-mediated C(sp2)-C(sp3) cross-coupling reactions between aryl grignard reagents and cyclic iodohydrine derivatives

trans-2-Arylcycloalcohol derivatives are obtained in high diastereoselectivity by the iron-mediated cross-coupling of cyclic TBS-protected iodohydrines with aryl Grignard reagents (see scheme; TBS=tert- butyldimethylsilyl). The stereoconvergent cross-coupling of a chiral TBS-protected 2-iodocyclohexanol provides the 2-arylcyclohexanols with no loss of stereochemical purity, and is a valuable alternative to the enantioselective opening of symmetrical epoxides. Copyright