1296155-64-0Relevant academic research and scientific papers
Synthesis of 5-alkynyl-2,2,6-trimethyl-1,3-dioxin-4-ones and 1,4-disubstituted-1,2,3-triazoles
Stefani, Helio A.,Vieira, Adriano S.,Amaral, Monica F.Z.J.,Cooper, Leora
, p. 4256 - 4261 (2011/08/22)
Herein we report an approach to the formation of 5-alkynyl-1,3-dioxin-4- ones using Suzuki-Miyaura cross-coupling reaction of potassium alkynyltrifluoroborate salts with 2,2,6-trimethyl-5-iodo-1,3-dioxin-4-one. The resulting 5-ethynyltrimethylsilyl-1,3-dioxin-4-ones obtained through the Sonogashira reaction were further reacted in a Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition to form functionalized 1,4-disubstituted-1,2,3-triazoles in good yields, using mild conditions and ultrasonic radiation to expedite the reaction.
