129624-94-8Relevant articles and documents
STRUCTURE-ACTIVITY RELATIONSHIP OF NSTX-3, SPIDER TOXIN OF NEPHILA MACULATA
Teshima, Tadashi,Matsumoto, Takahiro,Wakamiya, Tateaki,Shiba, Tetsuo,Nakajima, Terumi,Kawai, Nobufumi
, p. 3813 - 3818 (1990)
In a study on structure-activity relationship of spider toxin NSTX-3 obtained from venom of Nephila maculata, nine analogs or fragments of natural toxin were synthesized.Among them, des-Arg-NSTX-3 was found to be the minimum structure for blocking the excitatory transmission in the crustacean neuromuscular synapse.A positive charge of the arginine part was concluded to play the most important role for exhibition of the activity.