129630-19-9

Usage

Uses

Used in Metal Production Industry:
Potassium tellurate is used as a precursor in the production of tellurium metal, which is an essential component in various applications such as semiconductors, solar panels, and other electronic devices.
Used as a Catalyst in Organic Chemistry:
In the field of organic chemistry, potassium tellurate serves as a catalyst to facilitate specific reactions, enhancing the efficiency and selectivity of the processes involved.
Used in Dye and Pharmaceutical Synthesis:
Potassium tellurate is utilized in the synthesis of dyes and pharmaceuticals, contributing to the development of new compounds with potential applications in various industries.

InChI:InChI=1/C15H13Cl2F3N2O4/c1-3-24-11(23)6-25-10-4-7(9(18)5-8(10)16)13-12(17)14(22(2)21-13)26-15(19)20/h4-5,15H,3,6H2,1-2H3

Synthetic route

ethanol (64-17-5) + 3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}-5-difluoromethoxy-1-methylpyrazole → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Stage #1: 3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}-5-difluoromethoxy-1-methylpyrazole With sulfuryl dichloride; acetic acid In chlorobenzene at 40℃; for 1h; Stage #2: ethanol With sulfuric acid In chlorobenzene at 100℃; for 9h;	85.5%

ethyl 3-(4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl)acrylate → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: bromine / chlorobenzene / 1 h / 50 °C 2.1: chlorobenzene; methanol / 1 h / 40 °C 3.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 3.2: 2 h / 60 - 80 °C 4.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 5.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 5.2: 9 h / 100 °C View Scheme
Multi-step reaction with 6 steps 1.1: bromine / chlorobenzene / 1 h / 50 °C 2.1: triethylamine / chlorobenzene / 1.5 h / 40 - 70 °C 3.1: methanol / 1 h / 40 °C 4.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 4.2: 2 h / 60 - 80 °C 5.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 6.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 6.2: 9 h / 100 °C View Scheme

ethyl 2,3-dibromo-3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}propionate → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: chlorobenzene; methanol / 1 h / 40 °C 2.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 2.2: 2 h / 60 - 80 °C 3.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 4.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 4.2: 9 h / 100 °C View Scheme
Multi-step reaction with 5 steps 1.1: triethylamine / chlorobenzene / 1.5 h / 40 - 70 °C 2.1: methanol / 1 h / 40 °C 3.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 3.2: 2 h / 60 - 80 °C 4.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 5.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 5.2: 9 h / 100 °C View Scheme

ethyl 3-methoxy-3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}acrylate → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 1.2: 2 h / 60 - 80 °C 2.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 3.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 3.2: 9 h / 100 °C View Scheme

ethyl 2-bromo-3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}acrylate → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: methanol / 1 h / 40 °C 2.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 2.2: 2 h / 60 - 80 °C 3.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 4.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 4.2: 9 h / 100 °C View Scheme

3-{4-chloro-2-fluoro-5-(N-methylcarbamoylmethoxy)phenyl}-1-methylpyrazol-5-ol → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 2.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 2.2: 9 h / 100 °C View Scheme

5-bromo-2-chloro-4-fluorophenyl methyl carbonate (146447-08-7) → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 7 steps 1.1: sodium hydroxide / ethanol / 10 h / 20 °C 2.1: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere 3.1: bromine / chlorobenzene / 1 h / 50 °C 4.1: chlorobenzene; methanol / 1 h / 40 °C 5.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 5.2: 2 h / 60 - 80 °C 6.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 7.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 7.2: 9 h / 100 °C View Scheme
Multi-step reaction with 8 steps 1.1: sodium hydroxide / ethanol / 10 h / 20 °C 2.1: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere 3.1: bromine / chlorobenzene / 1 h / 50 °C 4.1: triethylamine / chlorobenzene / 1.5 h / 40 - 70 °C 5.1: methanol / 1 h / 40 °C 6.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 6.2: 2 h / 60 - 80 °C 7.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 8.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 8.2: 9 h / 100 °C View Scheme

N-methyl-(5-bromo-2-chloro-4-fluorophenoxy)acetic acid amide → 1-methyl-3-[2-fluoro-4-chloro-5-(ethoxycarbonylmethoxy)phenyl]-4-chloro-5-difluoromethoxypyrazole (129630-19-9)

Conditions	Yield
Multi-step reaction with 6 steps 1.1: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere 2.1: bromine / chlorobenzene / 1 h / 50 °C 3.1: chlorobenzene; methanol / 1 h / 40 °C 4.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 4.2: 2 h / 60 - 80 °C 5.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 6.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 6.2: 9 h / 100 °C View Scheme
Multi-step reaction with 7 steps 1.1: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Inert atmosphere 2.1: bromine / chlorobenzene / 1 h / 50 °C 3.1: triethylamine / chlorobenzene / 1.5 h / 40 - 70 °C 4.1: methanol / 1 h / 40 °C 5.1: hydrogenchloride / ethanol; water / 2 h / 60 °C 5.2: 2 h / 60 - 80 °C 6.1: tetrabutyl-ammonium chloride; sodium hydroxide / acetonitrile / 5 h / 20 °C 7.1: acetic acid; sulfuryl dichloride / chlorobenzene / 1 h / 40 °C 7.2: 9 h / 100 °C View Scheme

Upstream product

• 64-17-5 ethanol 
• 146447-08-7 5-bromo-2-chloro-4-fluorophenyl methyl carbonate 

Relevant academic research and scientific papers

MANUFACTURING METHOD OF PYRAZOLE DERIVATIVE AND INTERMEDIATE PRODUCTS THEREOF

PROBLEM TO BE SOLVED: To provide an improved manufacturing method of a compound expressed by a general formula (2) (in the general formula, R1, R2 or R3 is a (C1-C6) alkyl group), the compound useful as an intermediate product for a medical drug or an agricultural chemical, the improved manufacturing method desired due to a conventional manufacturing method of the compound (2) not being industrially advantageous in view of economical efficiency, environmental load and operation safety . SOLUTION: In a manufacturing method of a compound (2), a compound expressed by a general formula (5) (in the general formula, R1 and R2 are the same as in the above and X is a halogen atom) is successively or integrally reacted in a reaction vessel under a presence of bases. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom

There are disclosed a (3-substituted phenyl)pyrazole derivative represented by the general formula STR1 wherein R1, R2, R3, R4 and X are various substituents and a salt thereof, and its production process. Said pyrazole derivative or its salt is useful as a herbicide for controlling various injurious weeds.

3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts

There are disclosed a (3-substituted phenyl)-pyrazole derivative represented by the general formula wherein R1, R2, R3, R4 and X are various substituents and a salt thereof, and its production process. Said pyrazole derivative or its salt is useful as a herbicide for controlling various injurious weeds.