129639-79-8 Usage
Originator
Abafungin,York Pharma
Uses
Abafungin is a broad-spectrum antifungal agent.
Definition
ChEBI: A member of the class of guanidines that is tetrahydropyrimidin-2(1H)-imine in which the hydrogen of the imino group is replaced by a thiazol-2-yl group which in turn is substituted by a 2-(2,4-dimethylphenoxy)phenyl group at position 4
It has been used for the topical treatment of fungal nail infections.
Manufacturing Process
15.8 g (0.12 mole) N-(1,4,5,6-tetrahydropyrimidinyl)thiourea were added to
27.45 g (0.1 mole) 2-(2,4-dimethylphenoxy)phenacyl chloride in 100 ml
acetone and heated to reflux for 2 hours. On cooling the falling out product
was filtered off, washed with acetone and dried. N-[4-[2-(2,4-
Dimethylphenoxy)phenyl]-2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine
hydrochloride was prepared. Yield 91.4%; MP: 160°C.
20.72 g (0.05 mole) above product was stirred with 300 ml 1 N sodium
hydroxide for 30 minutes at room temperature. The insoluble product was
filtered off, washed and dried. Yield of N-[4-[2-(2,4-dimethylphenoxy)phenyl]-
2-thiazolyl]-1,4,5,6-tetrahydro-2-pyrimidinamine was 16.2 g (86%). MP:
191°-192°C.
Therapeutic Function
Antibacterial, Antifungal
Check Digit Verification of cas no
The CAS Registry Mumber 129639-79-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,6,3 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 129639-79:
(8*1)+(7*2)+(6*9)+(5*6)+(4*3)+(3*9)+(2*7)+(1*9)=168
168 % 10 = 8
So 129639-79-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25)