129644-61-7Relevant academic research and scientific papers
Lability of the trifluoromethyl group of trifluoromethoxybenzenes under HF/Lewis acid conditions
Belter, Randolph K.
scheme or table, p. 1302 - 1307 (2011/02/22)
The trifluoromethyl functionality of trifluoromethoxybenzenes (trifluoromethyl phenyl ethers) becomes labile under HF/Lewis acid conditions. Substrates with an unsubstituted para-position shed their -CF3 groups while performing a Friedel-Crafts reaction upon another substrate molecule's trifluoromethoxy group to generate p-rosolic acids. Substrates that had blocking groups at the para-positions reacted ortho. The electron donating substituents methoxy and phenoxy interfered with the formation of rosolic acids.
Antimycotically active substituted 2-aminothiazoles
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, (2008/06/13)
A 2-aminothiazole of the formula STR1 in which R1 represents hydrogen or alkyl and R2 represents a radical of the formula STR2 where R3, R4, R5 and R6 independently of one another in each case represent hydrogen, halogen, nitro, alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkylsulphinyl or halogenoalkylsulphonyl, X represents oxygen, sulphur, sulphinyl or sulphonyl and Ar represents an unsubstituted aryl or a substituted aryl radical, and their physiologically tolerable acid addition salts.
