129663-29-2

Upstream product

• 53252-49-6 5-benzylidene-2-methyl-4-oxo-4,5-dihydro-furan-3-carboxylic acid ethyl ester 
• 1229043-21-3 methyl 5-(1-hydroxy-2-phenylvinyl)-3-methylisoxazole-4-carboxylate 
• 1229043-20-2 methyl 5-benzylidene-2-methyl-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 1229043-19-9 methyl 2-methyl-4-oxo-4,5-dihydrofuran-3-carboxylate 
• 129663-16-7 ethyl 5-(1-hydroxy-2-phenylethenyl)-3-methylisoxazole-4-carboxylate 

Downstream Products

• 129663-36-1 4-Acetyl-6-benzyl-5-hydroxy-2H-pyridazin-3-one 
• 1229043-22-4 ethyl 2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-4(5H)-yl)acetate 
• 1374202-21-7 7-benzyl-5-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-20-6 7-benzyl-5-((4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-19-3 7-benzyl-5-((4-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-12-6 7-benzyl-3-methyl-5-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)methyl)isoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-10-4 7-benzyl-3-methyl-5-((5-(ethylamino)-1,3,4-thiadiazol-2-yl)methyl)isoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-09-1 7-benzyl-3-methyl-5-((5-(methylamino)-1,3,4-thiadiazol-2-yl)methyl)isoxazolo[4,5-d]pyridazin-4(5H)-one 
• 1374202-01-3 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide 
• 1374202-00-2 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-ethylthiosemicarbazide 
• 1374201-99-6 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-methylthiosemicarbazide 
• 1229043-23-5 2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-4(5H)-yl)acetohydrazide 

Relevant academic research and scientific papers

Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references

Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones

In this study, new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives having an N-acylhydrazone moiety were synthesized. The compounds were tested for their COX inhibitory activities using NS-398 and indomethacine as reference compounds. Although the compounds had an inhibitory profile against both COX-1 and COX-2, most were found to be more selective against COX-2 by a small percentage of inhibition, at the concentration of 50?μM. Docking studies were done to understand the interactions of the tested compounds with the active site of COX-2. It was observed that the compounds fit into, and interacted with, the hydrophobic parts which are common in the active pocket of COX-1 and COX-2 enzymes but could not fit to the area which is specific for COX-2 enzyme.

Synthesis of Isoxazolopyridazin-4(5H)-ones and 4-Acyl-5-hydroxy-3(2H)-pyridazinones

The title compounds were prepared from ethyl 5-acyl- or 5-(1-hydroxyethenyl)isoxazole-4-carboxylates which in turn were prepared from ethyl 3-methylamino-2-butenoate or 3(2H)-furanones.