1296644-95-5Relevant academic research and scientific papers
Substituted phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Sun, Wanying,Maletic, Milana,Mundt, Steven S.,Shah, Kashmira,Zokian, Hratch,Lyons, Kathy,Waddell, Sherman T.,Balkovec, James
scheme or table, p. 2141 - 2145 (2011/04/24)
3-(Phenylcyclobutyl)-1,2,4-triazoles were identified as inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1). They were shown to be active in the mouse in vivo pharmacodynamic model (PD) for HSD1 but exhibited a potent off-target activation of the
