1296672-75-7Relevant academic research and scientific papers
Synthesis of 2,5-diketopiperazine derivatives using 2-isocyanophenyl 4-methylbenzoate as a fragrant convertible isocyanide
Ji, Fei,Yi, Wen-Bin,Cai, Chun
, p. 1287 - 1292 (2015)
A new protocol in which 2-isocyanophenyl 4-methylbenzoate is used as a convertible isocyanide for Ugi/deprotection + activation/cyclization synthesis of 2,5-diketopiperazine derivatives has been developed. This operational simple procedure displays good functional group tolerance and avoids treatment of typically known offensive isocyanides.
A facile and rapid synthesis of N-benzyl-2-substituted piperazines
Jida, Mouhamad,Soueidan, Mohamad,Willand, Nicolas,Agbossou-Niedercorn, Francine,Pelinski, Lydie,Laconde, Guillaume,Deprez-Poulain, Rebecca,Deprez, Benoit
supporting information; experimental part, p. 1705 - 1708 (2011/04/26)
A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry.
