1296673-19-2Relevant academic research and scientific papers
A facile and rapid synthesis of N-benzyl-2-substituted piperazines
Jida, Mouhamad,Soueidan, Mohamad,Willand, Nicolas,Agbossou-Niedercorn, Francine,Pelinski, Lydie,Laconde, Guillaume,Deprez-Poulain, Rebecca,Deprez, Benoit
, p. 1705 - 1708 (2011/04/26)
A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry.
