129677-89-0 Usage
Description
Echinacea, also known as coneflower, is a perennial plant native to North America, specifically found in Missouri, Nebraska, and Kansas. It is well known for its ability to boost the body's immune system and possesses antiseptic, anti-bacterial, anti-itching, soothing, and moisturizing properties. Echinacea is a popular Native American remedy and has been extensively studied for its immunomodulating properties and chemical constituents.
Uses
Used in Medicinal Applications:
Echinacea is used as an immunomodulator for enhancing the body's immune system. It is particularly effective in treating skin lesions and shortening skin healing time due to its antiseptic and anti-bacterial properties.
Used in Skin Care Products:
Echinacea is used as an ingredient in skin care products for its anti-itching, soothing, and moisturizing properties, making it a valuable addition to acne preparations and other skincare formulations.
Used in Homeopathic Preparations:
Echinacea is used as a key component in various homeopathic preparations, with an estimated 800 echinacea-containing drugs in Germany alone. The plant's immunomodulating properties make it a popular choice for homeopathic remedies.
Used in Pharmaceutical Industry:
Echinacea is used as a source of various chemical constituents, such as inulin, inuloid, sucrose, betaine, phytosterols, and fatty acids like oleic, cerotic, lizolic, and palmitic. These constituents are derived from the plant's wood or bark and are utilized in the development of pharmaceutical products.
Indications
The purple coneflower Echinacea purpura, and its close
relatives, E. angustifolia and E. pallida, are the source of
the herb Echinacea, which is widely popular as a nonspecific
immune stimulant. These perennials are native
to the prairies of North America and are now widely
grown garden ornamentals.The root and aerial parts of
the plant are the portions used, and the preparation’s
potency can be verified by the transient tingling sensation
produced when it is tasted. Echinacea contains
alkamides, caffeic acid esters (echinacoside, cichoric
acid, caftaric acid), polysaccharides (heteroxylan), and
an essential oil. Some echinacea products are standardized
for their echinacoside content. In the past, adulteration
with American feverfew (Parthenium integrifolium)
was common. Echinacea is now sold either by
itself or in combination with golden seal or zinc for the
treatment of colds and influenza.
Mechanism of action
Echinacea extracts appear to stimulate the number and
activity of immune cells (i.e., increasing physiological
levels of tumor necrosis factor and other cytokines)and
to increase leukocyte mobility and phagocytosis.The extracts
also have antiviral and antiinflammatory properties
and inhibit bacterial hyaluronidase.
Clinical Use
There are numerous studies on echinacea in the literature,
many of which indicate either an in vitro immune
stimulation or a significant clinical reduction in the
severity and duration of upper respiratory viral symptoms,
especially when taken early in the onset of symptoms.
Despite several of these meta-analyses concluding
that echinacea is an effective immunomodulator of
acute infection, there is still controversy as to the extent
of its clinical effectiveness. A number of trials now
clearly indicate that echinacea is unlikely to be effective
in the prevention of colds, even if it may slightly shorten
their course.
In vitro antiinflammatory effects have been documented,
and the herb has a long history of being used
externally for wound healing, psoriasis, and the reduction
of skin irritation. Although there are a few small
positive studies, the available e
Side effects
Echinacea appears to be a very safe herb, producing only
minor gastrointestinal (GI) side effects and an occasional
allergic reaction, usually in atopic patients already sensitized
to other members of the Compositae plant family.
Anaphylaxis has occurred rarely. Use in HIV is discouraged
because of the concern that long-term therapy may
eventually suppress the immune system.
It is recommended that echinacea not be taken by
anyone for more than 8 continuous weeks, and most
clinical use is under 2 weeks’ duration. Echinacea has
not yet been shown to be safe in pregnant or breastfeeding
women and small children. No specific
herb–drug interactions are reported, but for theoretical
reasons those taking immunosuppressant drugs should
avoid echinacea.
Check Digit Verification of cas no
The CAS Registry Mumber 129677-89-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,6,7 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 129677-89:
(8*1)+(7*2)+(6*9)+(5*6)+(4*7)+(3*7)+(2*8)+(1*9)=180
180 % 10 = 0
So 129677-89-0 is a valid CAS Registry Number.