129678-97-3Relevant academic research and scientific papers
Addition of N-H bonds to iridium: Synthesis and characterization of N-Ir-H complexes and the observation that an iridium N-bonded indole ring becomes activated for Michael addition to alkynes
Ladipo, Folami T.,Merola, Joseph S.
, p. 131 - 138 (2015)
The thermal reaction between the electron-rich iridium complex, [IrCOD(PMe3)3]Cl, 1a, and pyrrolic or anilinic N-H bonds results in the oxidative addition of the N-H bond and the formation of an amido iridium hydride complex, HIr(amido)(Cl)(PMe3)3 with loss of COD. The only isomer formed in this reaction has a meridional arrangement of PMe3 ligands, with H trans to Cl and the amido group trans to PMe3. The reaction products of 1a with pyrrole, indole and 3-methyl indole were fully characterized included by single crystal X-ray diffraction. Attachment of the pyrrolic ring nitrogen to the iridium results in an electron rich ring system that is activated and adds to alkynes in a Michael addition reaction under mild conditions without a catalyst.
