1296889-89-8Relevant academic research and scientific papers
Spectral, biological screening, and DNA studies of metal chelates of 4-[N,N-bis-(3,5-dimethyl-pyrazolyl-1-methyl)]aminoantipyrine
Kalanithi,Rajarajan,Tharmaraj
, p. 1436 - 1445 (2011)
Tridentate chelate complexes of Co(II), Ni(II), and Cu(II) have been synthesized from 4-[N,Nbis-( 3,5-dimethyl-pyrazolyl-1-methyl)]aminoantipyrine. Microanalytical data, UV-Vis, magnetic susceptibility, Infrared, 1H- 13C-NMR, mass, thermal gravimetric analysis and electron paramagnetic resonance (EPR) techniques were used to confirm the structures. The electronic absorption spectra and magnetic susceptibility measurements suggest a distorted octahedral geometry for the metal. EPR spectra of the copper(II) complex at 77K confirm the distorted octahedral geometry of the copper(II) complex. The antimicrobial activities of the ligand and metal complexes against the bacteria such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter, Staphylococci, Streptococci, and the fungus Candida albicans have been carried out. A comparative study of minimum inhibitory concentration values of the ligand and its metal complexes indicates that metal complexes exhibit higher antibacterial and antifungal activity than the free ligand. The electrochemical behavior of copper(II) complex was studied by cyclic voltammetry. The complexes show nuclease activity in the presence of oxidant.
