129689-16-3

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 129688-68-2 2-[(4-Bromo-2-fluorophenyl)methyl]-6-fluoro-1,3(2H,3H)-isoquinolinedione 
• 1152315-50-8 6-fluorohomophthalic anhydride 

Downstream Products

• 1026709-55-6 (R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 129689-22-1 (S)-2-(4-Bromo-2-fluoro-benzyl)-4-carbamoylmethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 129688-50-2 minalrestat 
• 129689-20-9 (R)-2-(4-Bromo-2-fluoro-benzyl)-4-carboxymethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 129689-18-5 (S)-2-(4-Bromo-2-fluoro-benzyl)-4-carboxymethyl-6-fluoro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-Bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1

The high concentrations of plasma glucose formed during diabetic hyperglycemia rapidly translate into high levels of glucose in tissues where glucose uptake is independent of insulin. In these tissues that include the lens, retina, nerve, and kidney, this