129717-33-5

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 50625-53-1 (2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone 
• 1521-38-6 2,3-dimethoxybenzoic acid 

Downstream Products

• 1582229-72-8 3,5'-(azidomethylene)bis(1,2-dimethoxybenzene) 
• 1582229-75-1 (2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanamine hydrochloride 
• 1582229-78-4 N-((2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methyl)methanesulfonamide 

Relevant academic research and scientific papers

Synthesis and carbonic anhydrase isoenzymes i and II inhibitory effects of novel benzylamine derivatives

Synthesis and carbonic anhydrase inhibitory properties of novel diarylmethylamines 22-25 and sulfonamide derivatives 26-28 were investigated. Acylation of methoxy-substituted benzenes with benzene carboxylic acids, reduction of ketones with NaBH4, conversion of alcohols to azides, Pd-C catalyzed hydrogenation of azides afforded title compounds 22-25. Compounds 22, 24 and 25 were converted to sulfonamide derivatives 26-28 with MeSO2Cl. The inhibitory effects of novel benzylamine derivatives 22-28 were tested on human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes hCA I and II. The results demonstrated that compound 28 was found to be the best inhibitor against both hCA I (Ki: 3.68 μM) and hCA II (Ki: 9.23 μM).