129724-56-7

Upstream product

• 1415656-13-1 (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline 
• 1415656-14-2 (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline 
• 1415656-21-1 C₂₉H₃₉NO₆ 
• 1415656-22-2 C₂₄H₃₁NO₄ 
• 1415656-23-3 C₂₅H₃₃NO₄ 

Relevant academic research and scientific papers

Synthesis of the 1-phenethyltetrahydroisoquinoline alkaloids (+)-dysoxyline, (+)-colchiethanamine, and (+)-colchiethine

Asymmetric total syntheses of the 1-phenethyl-1,2,3,4- tetrahydroisoquinoline alkaloids (+)-dysoxyline (1), (+)-colchiethanamine (2), and (+)-colchiethine (3) are described. In the synthetic routes, coupling of a key, enatiomerically pure 1-(sulfonylmethyl)tetrahydroisoquinoline with aromatic aldehydes, performed by using the Julia-Kocienski reaction, afforded the corresponding 1-(β-styryl)-substituted tetrahydroisoquinolines with complete retention of the absolute configuration at the C1 carbon atom. Functionalization of the products generated in these processes by using four-or five-step sequences gave the target alkaloids 1-3.