1297273-69-8

Basic information

• Product Name: 11-((1-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine
• Synonyms: 11-((1-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine
• CAS NO: 1297273-69-8
• Molecular Weight: 631.648
• Mol File: 1297273-69-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11-((1-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine(CAS DataBase Reference)
• NIST Chemistry Reference: 11-((1-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine(1297273-69-8)
• EPA Substance Registry System: 11-((1-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-propylnoraporphine(1297273-69-8)

Safety Data

• Hazardous Substances Data: 1297273-69-8(Hazardous Substances Data)

Upstream product

• 41202-77-1 1-(2,3-dichlorophenyl)piperazine 
• 79640-92-9 (+/-)-11-Hydroxy-N-propylnoraporphine 
• 1297273-65-4 1-(3-azidopropyl)-4-(2,3-dichlorophenyl)piperazine 
• 1297273-50-7 11-prop-2-ynyloxy-N-propylnoraporphine 
• 956030-83-4 1-(3-chloropropyl)-4-(2,3-dichlorophenyl)piperazine 

Relevant articles and documents

Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands

A series of new aporphine analogues (aporlogues) were prepared from appropriate aporphine precursors and arylpiperazines using the Click reaction protocol. These compounds displayed good to high affinity at the D3 receptor, low or no affinity at the D1 and D2 receptors. Compounds 7f and 11c stood out as the most potent at the D3 receptor among our newly synthesized aporlogues with Ki values of 2.67 and 1.14 nM, respectively. Further assay at the 5-HT1A receptor revealed that aporlogues 7f and 11c also showed high affinity at this receptor with Ki values of 9.68 and 7.59 nM, respectively. They were 3.6- and 6.6-fold more potent at the D3 over 5-HT1A receptors. Such D3/5-HT1A dual property of these compounds may be useful in the treatment of several brain disorders.