1297292-35-3Relevant academic research and scientific papers
First total synthesis of (+)-vedelianin, a potent antiproliferative agent
Topczewski, Joseph J.,Wiemer, David F.
, p. 1628 - 1630 (2011)
The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S,3R,4aR,9aR)-isomer.
Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues
Gardner, Kevyn D.,Wiemer, David F.
, p. 1585 - 1592 (2016/03/01)
(Figure Presented) Pawhuskin A is a prenylated stilbene that functions as an antagonist of the kappa opioid receptor. Analogues of this natural product bearing different placements of the prenyl group in the A-ring have shown selectivity for either the ka
