1297364-84-1

Upstream product

• 351226-57-8 2-(chloromethyl)-1H-benzimidazole-5-carboxylic acid 
• 775227-99-1 2-((carboxymethylthio)methyl)-1H-benzo[d]imidazole-5-carboxylic acid 
• 1297364-82-9 1,3-dihydro-4H-benzo[4',5']imidazo[2,1-c][1,4]thiazine-4-one-8-carboxylic acid 

Relevant academic research and scientific papers

Novel benzimidazo[2,1-c][1,4]thiazinone derivatives with potent activity against HSV-1

The synthesis of new 2-carboxymethylsulfanylmethyl-1H-benzimidazole and 1,3-dihydro-4H-benzo[ 4′,5′]imidazo[2,1-c][1,4]thiazine-4-one-8- carboxylic acid derivatives was investigated. The antiviral activity of compounds 1-14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 μg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 μg and 50 μg.