129747-77-9

Usage

Uses

Used in Organic Synthesis:
3-(1H-PYRROL-1-YL)BENZALDEHYDE is used as a reagent in various organic synthesis reactions, serving as a key component in the creation of complex organic molecules.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 3-(1H-PYRROL-1-YL)BENZALDEHYDE is used as a building block for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
3-(1H-PYRROL-1-YL)BENZALDEHYDE is utilized in the production of agrochemicals, playing a crucial role in the synthesis of compounds that protect crops and enhance agricultural productivity.
Used in Fine Chemicals Industry:
3-(1H-PYRROL-1-YL)BENZALDEHYDE is also used as a building block in the manufacturing of fine chemicals, which are high-purity chemicals used in various specialized applications.
Used in Biological Research:
3-(1H-PYRROL-1-YL)BENZALDEHYDE is used as an acetylcholinesterase inhibitor in biological research, studying its potential to modulate the activity of this enzyme, which is involved in the breakdown of the neurotransmitter acetylcholine in the brain.
Used in Anti-inflammatory and Anticancer Research:
In the fields of anti-inflammatory and anticancer research, 3-(1H-PYRROL-1-YL)BENZALDEHYDE is explored for its potential therapeutic effects, with studies investigating its capacity to reduce inflammation and inhibit the growth of cancer cells.

InChI:InChI=1/C11H9NO/c13-9-10-4-3-5-11(8-10)12-6-1-2-7-12/h1-9H

Upstream product

• 131231-24-8 3-(pyridin-3-yl)benzaldehyde 
• 61471-45-2 3-(1H-pyrrol-1-yl)benzoic acid 
• 179055-25-5 3-(1H-pyrrol-1-yl)-N-methoxy-N-methylbenzamide 

Downstream Products

• 851958-50-4 (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanol 
• 179055-39-1 Cycloheptyl-(3-pyrrol-1-yl-benzyl)-amine 

Relevant academic research and scientific papers

Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas

A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.