1297537-37-1

Basic information

• Product Name: 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile
• Synonyms: 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile;2-chloro-4-(1H-pyrazol-3-yl)benzonitrile;ODM-201 int2;ODM-201 intermediate2;2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile(WX150050)
• CAS NO: 1297537-37-1
• Molecular Formula: C₁₀H₆ClN₃
• Molecular Weight: 203.62774
• EINECS: 941-761-7
• Mol File: 1297537-37-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 459.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 12.06±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile(1297537-37-1)
• EPA Substance Registry System: 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile(1297537-37-1)

Safety Data

• Hazardous Substances Data: 1297537-37-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(1H-pyrazol-5-yl)benzonitrile is a chemical compound that belongs to the class of benzonitriles. It consists of a benzene ring with a chlorine atom at the 2-position and a 1H-pyrazol-5-yl group at the 4-position. The presence of the benzonitrile group makes it a useful intermediate for the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities such as antimicrobial, antifungal, and anti-inflammatory properties. Additionally, it is used as a building block in organic synthesis for the preparation of novel compounds with diverse applications. Overall, 2-Chloro-4-(1H-pyrazol-5-yl)benzonitrile holds promise for its versatility and potential uses in the fields of medicine and agriculture.

Upstream product

• 154607-01-9 4-bromo-2-chlorobenzonitrile 
• 1297537-35-9 2-Chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile 
• 1297537-39-3 2-Chloro-4-(1H-pyrazol-5-yl)benzonitrile hydrochloride 
• 1297537-39-3 2-Chloro-4-(1H-pyrazol-3-yl)benzonitrile hydrochloride 
• 298-06-6 O,O-Diethyl hydrogen phosphorodithioate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 548797-51-9 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Downstream Products

• 1297540-14-7 (S)-4-(1-(2-aminobutyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile 
• 1297537-41-7 (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile 
• 1297537-33-7 (S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-phenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide 
• 1297537-95-1 (S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)isoxazole-3-carboxamide 
• 1297538-32-9 N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide 
• 1297539-13-9 (S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)isoxazole-3-carboxamide 
• 1297540-05-6 1-(5-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)-1H-pyrazol-3-yl)ethyl 2-(dimethylamino)acetate 
• 1297540-19-2 (S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1,2,5-oxadiazole-3-carboxamide 
• 1297542-22-3 (S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(chloromethyl)oxazole-4-carboxamide 
• 1297542-18-7 (S)-2-((1H-imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)oxazole-4-carboxamide 
• 1297542-60-9 (S)-2-(3-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamoyl)isoxazol-5-yl)propan-2-yl acetate 
• 1297542-94-9 (S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-((2,5-dioxopyrrolidin-1-yl)methyl)oxazole-4-carboxamide 
• 1297537-33-7 5-acetyl-N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-1H-pyrazole-3-carboxamide 
• 1403334-19-9 (S)-5-Chloro-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)pyrazine-2-carboxamide 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

The present invention provides substituted pyrazole compounds, compositions containing same, and use thereof. The substituted pyrazole compounds comprise a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound represented by formula (I) can serve as a tissue selective androgen receptor modulator (SARM), particularly serving as a drug for treating prostate cancer and other AR-dependent conditions and diseases in which AR antagonism is desired.

Pyrazoleamide derivative and synthesis method and application

The present invention discloses a pyrazoleamide derivative and a synthetic method and application as an androgen receptor antagonist and the preparation of anti-prostate cancer drugs. The present invention provides a method of synthesizing a pentabasole r

Method for preparing antitumor drug darolutamide

The invention relates to a method for preparing an antitumor drug darolutamide. A one-step Suzuki reaction is carried out, and then deprotection, hydroxylamine condensation and amide condensation reactions are carried out to obtain the darolutamide. The method has the advantages of few reaction steps, high reaction yield of each step, and simplicity in operation, so the total yield of the whole route is high, and the method has good experiment operationality.