1297537-45-1

Basic information

• Product Name: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID;ODM-201 int1;ODM-201 intermediate 1
• CAS NO: 1297537-45-1
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.12344
• Mol File: 1297537-45-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 257-269 °C (decomp)(Solv: ethanol (64-17-5); benzene (71-43-2))
• Boiling Point: 479.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.467±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.60±0.10(Predicted)
• CAS DataBase Reference: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(1297537-45-1)
• EPA Substance Registry System: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID(1297537-45-1)

Safety Data

• Hazardous Substances Data: 1297537-45-1(Hazardous Substances Data)

Usage

General Description

5-acetyl-1H-pyrazole-3-carboxylic acid is a chemical compound belonging to the family of Pyrazoles, which are polycyclic aromatic compounds containing a five-membered aromatic ring. Its molecular formula is C7H7NO3 with aromatic properties. This organic compound is identified by its systematic name 5-acetylpyrazole-3-carboxylic acid. There is limited publicly available information regarding its uses, physical properties, or potential hazards. It's strongly recommended that anyone intending to handle or use this chemical do so with the proper safety measures in place, as with any potentially hazardous chemical substance.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 1423-60-5 methyl ethynyl ketone 
• 40753-41-1 5-(1-methyl-2-phenyl-vinyl)-1⁽²⁾H-pyrazole-3-carboxylic acid 
• 37622-89-2 5-acetyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 1297537-33-7 5-acetyl-N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-1H-pyrazole-3-carboxamide 
• 1562404-69-6 (2S,4R)-4-[(5-acetyl-1H-pyrazole-3-carbonyl)amino]-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-ethoxymethyl-2-methylpentanoic acid 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

The present invention provides substituted pyrazole compounds, compositions containing same, and use thereof. The substituted pyrazole compounds comprise a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound represented by formula (I) can serve as a tissue selective androgen receptor modulator (SARM), particularly serving as a drug for treating prostate cancer and other AR-dependent conditions and diseases in which AR antagonism is desired.

Compound and process for synthesizing 5-acetyl-1H-pyrazole-3-carboxylic acid by using compound

The invention belongs to the field of chemical synthesis of substances and discloses a compound, application and a process for synthesizing 5-acetyl-1H-pyrazole-3-carboxylic acid by using the compound. A compound 2, 3-butanedione is used as a starting material to synthesize a compound intermediate III, the compound intermediate III is separated out from the system, the product conversion is promoted, the purification purpose can be achieved through filtration, the conversion rate reaches 95%, and the yield is increased; synthesis of an intermediate IV: by taking the intermediate III and a hydrazine compound as raw materials, the pH of the system is regulated, the yield is increased, and impurity production is reduced; after the reaction is ended, concentrating and filtering are carried out, so that the yield reaches 98%, and the HPLC purity is greater than 98.5%; and through the operation, high-purity V is obtained. The process of the invention is simple and safe, high in yield, suitable for industrialization, beneficial to impurity control and capable of reducing quality risks.

PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.