1297549-25-7

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 535-11-5 Ethyl 2-bromopropionate 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 

Downstream Products

• 1297549-32-6 ethyl (+)-(2S)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate 
• 1297549-30-4 ethyl (-)-(2R)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate 
• 1297549-27-9 ethyl (±)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate 

Relevant academic research and scientific papers

N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND THE USE THEREOF

The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

Chromatography-free wittig reactions using a bifunctional polymeric reagent

The first example of a polystyrene bearing two distinct reagent groups has been prepared. This phosphine and amine functionalized material was used in one-pot Wittig reactions with an aldehyde and either an α-halo-ester, -ketone, or -amide. Due to the heterogeneous nature of the polymer, the desired alkene product of these reactions could be isolated in excellent yield in essentially pure form after only filtration and solvent removal.