129760-38-9Relevant academic research and scientific papers
Stereochemical Investigation of a Phase Transfer Catalysed bis-Michael Spiroannulation Reaction.
Rele, Dinesh N.,Mathur, Hari H.,Trivedi, Girish K.,Chary, K. V. R.
, p. 1055 - 1078 (2007/10/02)
Spiroannulation has been achieved by double Michael reaction under very mild conditions using a phase transfer catalyst.Various cyclohexanone molecules having different steric requirements have been condensed with 1,5-diphenyl-1,4-pentadien-3-one in the presence of cetyltrimethylammonium bromide.This condensation reaction was found to be diastereospecific as well as regiospecific.Stereoisomers derived from homotopic cycloalkanones were found to adopt endo geometry, while diastereotopic cycloalkanones were found to elaborate a mixture of endo and exo diastereomers.These stereochemical inferences are drawn based on extensive 2D-nmr studies employing COSY and NOESY experiments.
