129768-54-3

Basic information

• Product Name: 3-Phenyl-1,4(1H)-benzodiazepin-2,5-dione
• Synonyms: 3-Phenyl-1,4(1H)-benzodiazepin-2,5-dione
• CAS NO: 129768-54-3
• Molecular Weight: 250.257
• Mol File: 129768-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Phenyl-1,4(1H)-benzodiazepin-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-1,4(1H)-benzodiazepin-2,5-dione(129768-54-3)
• EPA Substance Registry System: 3-Phenyl-1,4(1H)-benzodiazepin-2,5-dione(129768-54-3)

Safety Data

• Hazardous Substances Data: 129768-54-3(Hazardous Substances Data)

Upstream product

• 28144-70-9 anthranilic acid amide 
• 25726-04-9 phenylglyoxylyl chloride 
• 129768-51-0 2-(Phenylglyoxylyl)aminobenzamide 

Relevant articles and documents

Synthesis of chrysogine, a metabolite of Penicillium chrysogenum and some related 2-substituted 4-(3H)-quinazolinones

Syntheses of both enantiomers of chrysogine, 2-(α-hydroxyethyl)-4(3H)-quinazolinone, 1 from 2-ammobenzamide are reported. Thus reaction of 2-aminobenzamide and optically active α-acetoxypropionyl chloride gave 9, which upon saponification and cyclization induced by aqueous sodium carbonate at room temperature gave chrysogine. The enantiomeric purity of 1 was determined by NMR. Inversion of (-)-(S)-1, using the Mitsunobo reaction, gave (+)-(R)-1. Reduction of 2-acetyl-4(3H)-qumazolinone 2 with baker's yeast gave the S-enantiomer of 1. The cyclization method used could be extended and a number of 2-(a-hydroxy)alkyl-4-(3H)-quinazolinones are also reported.