129778-54-7

Upstream product

• 129778-45-6 Acetic acid (3R,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2-nitro-phenylsulfanyl)-tetrahydro-furan-2-yl ester 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 129778-56-9 (3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(2-nitro-phenylsulfanyl)-dihydro-furan-2-one 
• 125440-13-3 (S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-trimethylsilanyloxy-2,3-dihydro-furan 
• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 

Downstream Products

• 3056-17-5 stavudin 

Relevant academic research and scientific papers

A general method for controlling glycosylation stereochemistry in the synthesis of 2′-deoxyribose nucleosides

Glycosylation reactions of 2-arylsulfinyl-O-acetylribosides6 with silylated thymine11 produce 2′-deoxyribose nucleosides with high β-selectivity. An application of this directing effect in the synthesis of the antiretroviral agent D4T,2, is described. Glycosylation reactions of 2-arylsulfinyl-O-acetylribosideswith silylated thymine produce 2′-deoxyribose nucleosides with high β-selectivity. An application of this directing effect in the synthesis of the antiretroviral agent D4T is described. (Chemical Equation Presented).