129793-82-4

Basic information

• Product Name: Ethanone, 1-(2,4-difluorophenyl)-2-(3-pyridinyl)-
• Synonyms: 1-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone;1-(2,4-Difluoro-phenyl)-2-pyridin-3-yl-ethanone
• CAS NO: 129793-82-4
• Molecular Formula: C13H9F2NO
• Molecular Weight: 233.217
• Mol File: 129793-82-4.mol

Chemical Properties

• Boiling Point: 355.2±32.0 °C(Predicted)
• Density: 1.272±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2,4-difluorophenyl)-2-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2,4-difluorophenyl)-2-(3-pyridinyl)-(129793-82-4)
• EPA Substance Registry System: Ethanone, 1-(2,4-difluorophenyl)-2-(3-pyridinyl)-(129793-82-4)

Safety Data

• Hazardous Substances Data: 129793-82-4(Hazardous Substances Data)

Upstream product

• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 106614-28-2 methyl 2,4-difluorobenzoate 

Downstream Products

• 129793-83-5 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one 
• 129793-84-6 2-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane 

Relevant articles and documents

Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

Replacement of one triazole ring of fluconazole with 4-pyridinyl leads to an increase in activity against Aspergillus fumigatus. Introduction of an α-methyl group has a marked additional beneficial effect. Investigation of pyridinyl and pyrimidinyl analogues resulted in the identification of 30 (UK-109,496), voriconazole) which has excellent potency against a broad range of fungal pathogens including A. fumigatus and Candida krusei.

Triazole antifungal agents

The invention provides antifungal agents of the formula: STR1 and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF3 ; R1 is C1 -C4 alkyl; R2 is H or C1 -C4 alkyl; and "Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C1 -C4 alkyl, C1 -C4 alkoxy, halo, CF3, CN, NO2, NH2, --NH(C1 -C4 alkanoyl) or --NHCO2 (C1 -C4 alkyl).