1297961-53-5

Upstream product

• 1297961-62-6 (4-morpholin-4-yl-benzyl)-[(triisopropylsilanyl)-ethynyl]-carbamic acid t-butyl ester 

Downstream Products

• 1383718-11-3 [3-(2,4-bis-benzyloxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-benzyl)-carbamic acid tert-butyl ester 
• 1383718-12-4 tert-butyl 1-(2,4-dihydroxy-5-isopropylphenyl)-1H-[1,2,3]triazol-5-yl (4-morpholinobenzyl)carbamate 
• 1383717-47-2 4-isopropyl-6-[5-(4-morpholin-4-yl-benzylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol 

Relevant academic research and scientific papers

ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY

The present invention relates to aryl triazole derivatives of Formula I having antitumoural activity through, as one possible biological target, the molecular chaperone heat shock protein 90 (Hsp90) inhibition. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of Hsp90 is responsive, and the pharmaceutical composition containing such compounds.