129801-20-3Relevant academic research and scientific papers
FLUORINE-CONTAINING AMINO ACIDS. V. IMINES OF TRIFLUOROPYRUVIC ACID IN THE SYNTHESIS OF N-SUBSTITUTED TRIFLUOROALANINES
Soloshonok, V. A.,Yagupol'skii, Yu. L.,Kukhar, V. P.
, p. 1478 - 1482 (2007/10/02)
N-Substituted trifluoroalanine methyl esters were obtained by the reduction of the corresponding imines of trifluoropyruvic acid with zinc in acetic acid.The N-butyl- and N-(1-phenylethyl)imines undergo a -proton shift under the influence of bases with the formation of trifluoroalanine derivatives.It was found that the N-(1-phenylethyl)imine of tetrafluoropyruvic acid is formed directly from the corresponding amine and methyl trifluoropyruvate under conditions with azeotropic distillation of the water with toluene in the presence of acidic catalysis.
