1298023-69-4 Usage
Uses
Used in Pharmaceutical Research:
CAY10654 is used as a research tool for studying the role of mPGES-1 in inflammation and pain. Its high selectivity and efficacy in inhibiting mPGES-1 make it a valuable compound in understanding the underlying mechanisms of these conditions and exploring potential therapeutic interventions.
Used in Anti-inflammatory Drug Development:
CAY10654 is used as a potential anti-inflammatory agent, targeting the mPGES-1 enzyme to reduce the production of PGE2. This approach may help in managing inflammation and pain associated with various conditions, such as arthritis, asthma, and other inflammatory disorders.
Used in Pain Management Research:
CAY10654 is used as a pain management research compound, focusing on its ability to inhibit the production of PGE2, a known mediator of pain. This research aims to develop new pain management strategies and therapies that could potentially offer more effective and targeted treatment options for patients suffering from chronic or acute pain.
Used in Drug Delivery Systems:
CAY10654 is used in the development of drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. Various organic and metallic nanoparticles have been explored as carriers for CAY10654, aiming to enhance its effectiveness in targeting mPGES-1 and reducing inflammation and pain.
Check Digit Verification of cas no
The CAS Registry Mumber 1298023-69-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,8,0,2 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1298023-69:
(9*1)+(8*2)+(7*9)+(6*8)+(5*0)+(4*2)+(3*3)+(2*6)+(1*9)=174
174 % 10 = 4
So 1298023-69-4 is a valid CAS Registry Number.
1298023-69-4Relevant academic research and scientific papers
Immunosuppressive but non-LasR-inducing analogues of the pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-l-homoserine Lactone
Jadhav, Gopal P.,Chhabra, Siri Ram,Telford, Gary,Hooi, Doreen S. W.,Righetti, Karima,Williams, Paul,Kellam, Barrie,Pritchard, David I.,Fischer, Peter M.
, p. 3348 - 3359 (2011/07/08)
Figure Presented. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone (1) is involved not only in bacterial activation but also in subversion of the host immune system, and this compound might thus be used as a template to design immunosuppressive agents, provided derivatives devoid of quorum-sensing activity could be discovered. By use of a leukocyte proliferation assay and a newly developed bioluminescent P. aeruginosa reporter assay, systematic modification of 1 allowed us to delineate the bacterial LasR-induction and host immunosuppressive activities. The main determinant is replacement of the methylene group proximal to the β-ketoamide in the acyl chain of 1 with functions containing heteroatoms, especially an NH group. This modification can be combined with replacement of the homoserine lactone system in 1 with stable cyclic groups. For example, we found the simple compound N1-(5-chloro-2-hydroxyphenyl)-N 3-octylmalonamide (25d) to be over twice as potent as 1 as an immune suppressor while displaying LasR-induction antagonist activity.
