1298030-04-2Relevant articles and documents
Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold
Chen, Xin,Yang, Yanchun,Ma, Bing,Zhang, Shuzhen,He, Minlan,Gui, Dequan,Hussain, Saghir,Jing, Chaojun,Zhu, Changjin,Yu, Qun,Liu, Yan
, p. 1536 - 1544 (2011/05/06)
A series of pyrido[2,3-e]-[1,2,4]-thiadiazine 1,1-dioxide acetic acid derivatives were synthesized and tested for their inhibitory activity against aldose reductase (ALR2). These derivatives were found to be potent aldose reductase inhibitors with IC