1298083-39-2Relevant academic research and scientific papers
Synthesis and anticancer activity of new 2-aryl-4h-3,1-benzothiazines
Niewiadomy, Andrzej,Matysiak, Joanna,Karpinska, Monika M.
experimental part, p. 224 - 230 (2011/11/06)
New compounds of 2-aryl-4H-3,1-benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl-modified sulfinylbis((2,4-dihydroxyphenyl)methanethione) with 2-aminobenzyl alcohols. The reaction proceeded through thiobenzanilide intermediates, which were converted to the 4H-3,1-benzothiazine fused ring by an endocyclization process. The structures of compounds were identified from elemental, IR, 1H-NMR, 13C-NMR, and MS spectra analyses. The cytotoxicity in vitro against four human cancer cell lines was determined. The antiproliferative properties of some compounds were more beneficial than cisplatin studied comparatively.
