1298085-86-5

Upstream product

• 1298085-71-8 (2Z,4R,5R,9S,10S,11Z)-11-(benzoyloxy)-4,10-dimethyl-7-methylene-9-[(1S)-1-phenylethoxy]-5-{(1R)-1-[4-(trifluoromethyl)phenyl]ethoxy}-2,11-tridecadien-3-yl benzoate 
• 1298085-78-5 (2Z,4R,5R,9S,10S,12S,13R)-13-hydroxy-4,10,12,14-tetramethyl-7-methylidene-11-oxo-5-{(1R)-1-[4-(trifluoromethyl)phenyl]ethoxy}pentadec-2-ene-3,9-diyl dibenzoate 
• 1298085-79-6 C₄₂H₅₁F₃O₆Si 
• 1298085-80-9 (2Z,4R,5R,9S,10R,11R,12S,13R)-11,13-dihydroxy-4,10,12,14-tetramethyl-7-methylidene-5-{(1R)-1-[4-(trifluoromethyl)phenyl]ethoxy}pentadec-2-ene-3,9-diyl dibenzoate 
• 1298085-81-0 (2Z,4R,5R,9S,10R)-4-methyl-7-methylidene-5-{(1R)-1-[4-(trifluoromethyl)phenyl]ethoxy}-10-[(4S,5S,6R)-2,2,5-trimethyl-6-(propan-2-yl)-1,3-dioxan-4-yl]undec-2-ene-3,9-diyl dibenzoate 
• 1298085-83-2 (2R,4S,5R,7R,8R,12S,13S)-1-(Benzyloxy)-4,12-dihydroxy-2-[(4-methoxybenzyl)oxy]-5,7-dimethyl-10-methylidene-8-{(1R)-1-[4-(trifluoromethyl)phenyl]ethoxy}-13-[(4S,5S,6R)-2,2,5-trimethyl-6-(propan-2-yl)-1,3-dioxan-4-yl]tetradecan-6-one 

Relevant academic research and scientific papers

Concise synthesis of complicated polypropionates through one-pot dissymmetrical two-directional chain elongation

Herein, a major breakthrough in a sulfur dioxide-mediated oxyallylation cascade reaction is reported that allows the preparation of complex long-chain polyketide fragments with more than ten stereogenic centers through a carefully designed desymmetrization process. An allylbissilane is combined, under the appropriate reaction conditions, with two different 1,3-dioxy-1,3-dienes permitting the construction of a 13-membered polypropionate precursor in one pot. Four stereocenters are selectively created during this process. The so-obtained pseudo-C2- or -CS-symmetric products are desymmetrized through selective deprotection and can be selectively elongated in both directions using aldol chemistry. Copyright