1298086-80-2

Basic information

• Product Name: C₂₈H₂₆F₆N₆O₆S
• CAS NO: 1298086-80-2
• Molecular Weight: 688.607
• Mol File: 1298086-80-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₆F₆N₆O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₆F₆N₆O₆S(1298086-80-2)
• EPA Substance Registry System: C₂₈H₂₆F₆N₆O₆S(1298086-80-2)

Safety Data

• Hazardous Substances Data: 1298086-80-2(Hazardous Substances Data)

Upstream product

• 1311150-14-7 C₂₆H₂₃F₆N₅O₇S 
• 1311150-12-5 C₂₅H₂₁F₆N₅O₇S 
• 765-30-0 Cyclopropylamine 

Relevant articles and documents

SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl) piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Described herein is the initial optimization of (+/-) N-benzyl-4- heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamide (1), a hit discovered in a high throughput screen run against the NS5B polymerase enzyme of the hepatitis C virus. This effort resulted in the identification of (S)-N-sec-butyl-6-((R)-3- (4-(trifluoromethoxy)benzylcarbamoyl)-4-(4-(trifluoromethoxy)phenylsulfonyl) piperazin-1-yl)pyridazine-3-carboxamide (2), that displayed potent replicon activities against HCV genotypes 1b and 1a (EC50 1b/1a = 7/89 nM).