1298097-12-7

Basic information

• Product Name: (3,5-bis(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)(benzofuran-2-yl)methanone
• Synonyms: (3,5-bis(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)(benzofuran-2-yl)methanone
• CAS NO: 1298097-12-7
• Molecular Weight: 435.309
• Mol File: 1298097-12-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3,5-bis(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)(benzofuran-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-bis(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)(benzofuran-2-yl)methanone(1298097-12-7)
• EPA Substance Registry System: (3,5-bis(4-chlorophenyl)-4,5-dihydropyrazol-1-yl)(benzofuran-2-yl)methanone(1298097-12-7)

Safety Data

• Hazardous Substances Data: 1298097-12-7(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 42974-19-6 benzo[b]furan-2-carbohydrazide 
• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 3199-61-9 ethyl coumarilate 

Relevant articles and documents

Synthesis of some novel benzofuran-2-yl(4,5-dihyro-3,5-substituted diphenylpyrazol-1-yl) methanones and studies on the antiproliferative effects and reversal of multidrug resistance of human MDR1-gene transfected mouse lymphoma cells in vitro

A new series of benzofuran-2-yl(4,5-diydro-3,5-substituted diphenylpyrazol-1-yl) methanone derivatives 8a-x by the reaction of the benzofuran-2-carbohydrazides 7 with various chalcone derivatives 3a-x using microwave irradiation has been described. The effect of synthesized compounds 8a-v was studied against human cancer cell lines for their antiproliferative activity and reversal of multidrug resistance on human MDR1-gene transfected mouse lymphoma cells. Among the 24 compounds, the 8c and 8h showed good antiproliferative activity 8b, 8f and 8k were exhibited good MDR reversal activity. The main significance of the process is easy workup process, short reaction time and high yield of the new compounds for biological interest. However, the studies on genetically modified multidrug resistant cancer cells are costly and time consuming.