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1298116-74-1

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1298116-74-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1298116-74-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,8,1,1 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1298116-74:
(9*1)+(8*2)+(7*9)+(6*8)+(5*1)+(4*1)+(3*6)+(2*7)+(1*4)=181
181 % 10 = 1
So 1298116-74-1 is a valid CAS Registry Number.

1298116-74-1Downstream Products

1298116-74-1Relevant articles and documents

Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis

Wang, Penghui,Wang, Xuewei,Wang, Zhengning,Zhao, Junfeng

supporting information, p. 10374 - 10381 (2021/07/26)

Allenone has been identified as a highly effective peptide coupling reagent for the first time. The peptide bond was formed with an α-carbonyl vinyl ester as the key intermediate, the formation and subsequent aminolysis of which proceed spontaneously in a racemization-/epimerization-free manner. The allenone coupling reagent not only is effective for the synthesis of simple amides and dipeptides but is also amenable to peptide fragment condensation and solid-phase peptide synthesis (SPPS). The robustness of the allenone-mediated peptide bond formation was showcased incisively by the synthesis of carfilzomib, which involved a rare racemization-/epimerization-free N to C peptide elongation strategy. Furthermore, the successful synthesis of the model difficult peptide ACP (65-74) on a solid support suggested that this method was compatible with SPPS. This method combines the advantages of conventional active esters and coupling reagents, while overcoming the disadvantages of both strategies. Thus, this allenone-mediated peptide bond formation strategy represents a disruptive innovation in peptide synthesis.

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