1298130-59-2Relevant academic research and scientific papers
Antidotes to anthrax lethal factor intoxication. Part 2: Structural modifications leading to improved in vivo efficacy
Kim, Seongjin,Jiao, Guan-Sheng,Moayeri, Mahtab,Crown, Devorah,Cregar-Hernandez, Lynne,McKasson, Linda,Margosiak, Stephen A.,Leppla, Stephen H.,Johnson, Alan T.
, p. 2030 - 2033 (2011/05/02)
New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.
