129833-22-3

Upstream product

• 87-60-5 3-chloro-2-methylbenzenamine 
• 129833-34-7 4-Chloro-2-iodo-3-methyl-benzoic acid 
• 98968-68-4 2-amino-4-chloro-3-methylbenzoic acid 
• 6374-90-9 6-Chloro-7-methyl-1H-indole-2,3-dione 
• 129833-43-8 2-(2-Carboxymethyl-phenoxy)-4-chloro-3-methyl-benzoic acid 

Relevant academic research and scientific papers

Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.