129835-19-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 958-09-8 2'-deoxy-D-adenosine 
• 129835-18-3 (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-3-ol 

Downstream Products

• 305819-98-1 9-(2-deoxy-3-C-phosphono-5-O-tert-butyldiphenylsilyl-β-D-threo-pentofuranosyl)adenine 
• 129835-18-3 (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-3-ol 
• 87432-46-0 9-(5-O-TPS-2-deoxy-β-D-threo-pentofuranosyl)adenine 

Relevant academic research and scientific papers

Convenient syntheses of 3′-amino-2′,3′- dideoxynucleosides, their 5′-monophosphates, and 3′-aminoterminal oligodeoxynucleotide primers

(Chemical Equation Presented) 5′-Protected 3′-amino-2′, 3′-dideoxynucleosides containing any of the four canonical nucleobases (A/C/G/T) were prepared via azides in five to six steps, starting from deoxynucleosides. For pyrimidines, the synthetic route in

Efficient synthesis of 2'-deoxynucleoside 3'-C-phosphonates: Reactivity of geminal hydroxyphosphonate moiety

In this report we present a novel, simple way for the synthesis of 3'-C-phosphonate derivatives of all four basic 2'-deoxynucleosides in both fully protected and deprotected forms. The reactivity of the geminal hydroxy phosphonate moiety located at the 3'

Mild Periodinane Oxidation of Protected Nucleosides to Give 2'- and 3'-Ketonucleosides. The First Isolation of a Purine 2'-Deoxy-3'-ketonucleoside Derivative

Oxidation of 3',5'- or 2',5'-bis-O-silyl-protected nucleosides with Dess-Martin 12-I-5 periodinane reagent, 1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one (I), in dichloromethane gives 2'- or 3'-ketonucleoside derivatives, respectively.Isolation of the first purine 2'-deoxy-3'-ketonucleoside derivative (2d) has been accomplished by periodinane oxidation of 5'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosine (1d).