129846-94-2

Basic information

• Product Name: 2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline
• Synonyms: 2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline
• CAS NO: 129846-94-2
• Molecular Formula: C₁₃H₁₂FNO₂S₂
• Molecular Weight: 297.3682832
• Mol File: 129846-94-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline(129846-94-2)
• EPA Substance Registry System: 2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline(129846-94-2)

Safety Data

• Hazardous Substances Data: 129846-94-2(Hazardous Substances Data)

Usage

General Description

2-(2-fluorophenylthio)-5-(Methylsulfonyl)aniline, also known as FSC-008, is a chemical compound that belongs to the class of organosulfur compounds. It is commonly used in the synthesis of pharmaceuticals and agrochemicals as a building block or intermediate. This chemical has the molecular formula C13H12FNO2S2 and a molecular weight of 305.37 g/mol. It is a pale yellow solid with a melting point of 101-103°C and is soluble in organic solvents such as ethanol and dimethyl sulfoxide. FSC-008 possesses antimicrobial and antifungal properties, making it a valuable compound for the development of new pharmaceuticals and agricultural products. However, its potential toxicity and environmental impact should be carefully evaluated before widespread use.

Upstream product

• 97-07-4 1-chloro-4-methanesulfonyl-2-nitrobenzene 
• 2557-78-0 2-fluorothiophenol 
• 129846-91-9 2-(2-fluorophenylthio)-5-(methylsulfonyl)nitrobenzene 

Downstream Products

• 14008-44-7 metopimazine 
• 23503-68-6 2-(methylsulfonyl)-10H-phenothiazine 

Relevant articles and documents

New process for preparing metopimazine

The invention discloses a new process for preparing metopimazine. The new process comprises the following steps: in a reactor, using o-fluorothiophenol and 1-chloro-4-(methylsulphonyl)-2-nitrobenzeneas raw materials to react in acetone to obtain 2-(2-fluorophenyl thio)-5-(methylsulfonyl) nitrobenzene; then adding ethanol and ferric chloride for a heating reaction to generate 2-(2-fluorophenyl thio)-5-(methylsulfonyl) aniline; adding dimethyl sulfoxide, adding NaH, heating for reaction, cooling to a room temperature, adding water, and stirring to prepare 2-methylsulfonyl-10H-phenothiazine; then adding 10-acetyl-2-methylsulfoxide-10H phenothiazine and potassium hydroxide to react to prepare 10-acetyl-2-methylsulfonyl-(5-sulfoxide)-10H phenothiazine; adding acetone, carrying out concentration and extraction to obtain a methylene chloride solution of 10-acetyl-2-methylsulfonyl-10H phenothiazine; adding piperidine-4-formamide after the temperature is lowered; adding sodium borohydride acetate; carrying out reaction and filtration; and pulping filter cakes to obtain metopimazine. According to the new process provided by the invention, the final yield is greatly improved by optimizing the reaction route and reaction conditions, and the product purity reaches 99.3% or higher.