129880-96-2Relevant academic research and scientific papers
Inter- And intramolecular photoinduced electron transfer of flavin derivatives with extremely small reorganization energies
Murakami, Motonobu,Ohkubo, Kei,Fukuzumi, Shunichi
, p. 7820 - 7832 (2010)
Photoinduced electron transfer (ET) of a series of aromatic electron donors (D) to the singlet or triplet excited state of a flavin analogue (10methylisoalloxazine: MeFl) and intermolecular back electron transfer (BET) from MeFl to D+ in benzon
A versatile method for the synthesis of benzimidazoles from o-nitroanilines and aldehydes in one step via a reductive cyclization
Yang, Donglai,Fokas, Demosthenes,Li, Jingzhou,Yu, Libing,Baldino, Carmen M.
, p. 47 - 56 (2007/10/03)
A highly efficient and versatile method for the synthesis of benzimidazoles was achieved in one step via the Na2S2O4 reduction of o-nitroanilines in the presence of aldehydes. Heating a solution of o-nitroaniline (Ic) and an aldehyde in EtOH or another appropriate solvent, in the presence of aqueous or solid Na2S2O4, provided facile access to a series of 2-substituted N-H benzimidazoles 5a-m containing a wide range of functional groups not always compatible with the existing synthetic methods. This methodology has also been applied to the regioselective synthesis of N-alkyl and N-aryl benzimidazoles 6a-f via the cyclization of the corresponding N-substituted nitroanilines 13a-e, respectively. In addition, the method was applied successfully to the synthesis of other imidazole containing heterocyclic ring systems such as 1H-imidazo[4,5-b]pyridines 14a,b and 1H-imidazo[4,5-f]quinoline 15.
Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl)flavins
Cowden,Halladay,Cunningham,Hunt,Clark
, p. 1818 - 1822 (2007/10/02)
A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.
New Modified Preparation of 2-Nitrodiarylamines
Zhu, Yun-Fei,Lin, Guo-Qiang,Chen, Yu-Qun
, p. 430 (2007/10/02)
2-Nitrodiarylamines are prepared in good yields from 2-chloronitrobenzene and anilines in the presence of potassium fluoride without solvent at 160-170 deg C.
