129884-37-3

Upstream product

• 102312-67-4 rac-(trans)-cyclohex-4-ene-1,2-diamine dihydrochloride 
• 129884-38-4 (1R,2S)-Cyclohex-4-ene-1,2-diamine; compound with sulfuric acid 
• 502903-60-8 cis-cyclohex-4-ene-1,2-diazide 
• 623549-64-4 Methanesulfonic acid (1R,6S)-6-methanesulfonyloxy-cyclohex-3-enyl ester 
• 406682-04-0 cis-cyclohex-4-ene-1,2-diol 
• 1165952-92-0 cyclohexa-1,4-diene 

Downstream Products

• 208533-46-4 (1R,2R)-1,2-bis(N,N’-tert-butyloxycarbonylamino)-4-cyclohexene 
• 623549-61-1 N-[6-(2,2,2-trifluoroacetylamino)cyclohex-3-enyl]-2,2,2-trifluoroacetamide 
• 623549-50-8 N-[6-(2,2,2-trichloroacetylamino)cyclohex-3-enyl]-2,2,2-trichloroacetamide 
• 129905-05-1 5-((3aS,7aR)-1-Benzyl-3a,4,7,7a-tetrahydro-1H-benzoimidazol-2-yl)-pentanoic acid 3-hydroxy-2-hydroxymethyl-2-methyl-propyl ester 
• 129884-42-0 1-benzyl-2-<4-(4-methyl-2,6,7-trioxabicyclo<2.2.2>oct-1-yl)butyl>-3a,4,7,7a-tetrahydro-1H-benzimidazole 
• 129884-46-4 1-benzyl-2-(4-methoxycarbonylbutyl)-3a,4,7,7a-tetrahydro-1H-benzimidazole 
• 129884-41-9 1-benzyl-2-methyl-3a,4,7,7a-tetrahydro-1H-benzimidazole 

Relevant academic research and scientific papers

Scope of the directed dihydroxylation: Application to cyclic homoallylic alcohols and trihaloacetamides

The synthesis and directed dihydroxylation of a range of cyclic alkenes was investigated. Both homoallylic alcohols and homoallylic trihaloacetamides were found to be efficient directing groups, giving rise to good to excellent levels of remote asymmetric induction with OsO4-TMEDA. Interestingly, in all cases examined, trifluoroacetamides were found to be superior to trichloroacetamides as directing groups and an argument is presented which rationalises this observation.

Synthesis of [3H2]-(R,R)-1,2-diaminocyclohexaneoxalatoplatinum(II), [3H2]-oxaliplatin

A synthesis of [3H2]-(R,R)-1,2-diaminocyclohexaneoxalatoplatinum(II), [3H2]-Oxaliplatin, 2, is described, rac-trans-4-Cyclohexene-1,2- dicarboxylic acid diethyl ester, 6, was converted to rac-trans-1,2- diaminoc

2-Methyl-4,5-dihydroimidazole as a Doubly Nucleophilic Unit: Preparation of Dihydroimidazole Azaprostanoids

2-Methyl-4,5-dihydroimidazole is incorporated as a doubly nucleophilic synthon, by successive alkylations at N-1 and C-2(Me), into monocyclic 9,12- and 8,11-diazaprostanoids containing the dihydroimidazole moiety. 2-Methyl-3a,4,7,7a-tetrahydrobenzimidazole is prepared (from 1,2,3,6-tetrahydrophthalic anhydride) and elaborated in the same way into a diazaprostacyclin precursor.