129885-18-3Relevant articles and documents
Synthesis and Antiarrhythmic Activity of cis-2,6-Dimethyl-α,α-diaryl-1-piperidinebutanols
Hoefle, M. L.,Blouin, L. T.,Fleming, R. W.,Hastings, S.,Hinkley, J. M.,et al.
, p. 12 - 19 (2007/10/02)
A series of α,α-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model.Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best antiarrhythmic