1299358-21-6Relevant articles and documents
Synthetic studies towards leiodermatolide: Rapid stereoselective syntheses of key fragments
Navickas, Vaidotas,Rink, Christian,Maier, Martin E.
, p. 191 - 194 (2011/03/22)
The synthesis of three key fragments of the novel 16-membered macrolide leiodermatolide is described. The stereotetrad-containing building block was prepared via a Marshall-Tamaru reaction on an aldehyde obtained by organocatalysis. For a second building block, a Marshall-Tamaru reaction was used as well. The side-chain fragment containing a hydroxy δ-lactone could be obtained by intramolecular Reformatsky reaction. Georg Thieme Verlag Stuttgart.