129979-57-3 Usage
Description
Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively. It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM). In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
Check Digit Verification of cas no
The CAS Registry Mumber 129979-57-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,9,7 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 129979-57:
(8*1)+(7*2)+(6*9)+(5*9)+(4*7)+(3*9)+(2*5)+(1*7)=193
193 % 10 = 3
So 129979-57-3 is a valid CAS Registry Number.
InChI:InChI=1/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
129979-57-3Relevant articles and documents
NEW SYTHESIS OF VASOPRESSIN AND ITS DE-9-GLYCINE ANALOGS
Panseuvich, O. S.,Chipens, G. I.,Korps, A. O.,Pavar, A. P.
, p. 370 - 375 (2007/10/02)
A unified scheme is proposed for the synthesis of vasopressin (I), de-9-glycinevasopressin (II), and de-9-glycinamidevasopressin (III) which has been developed on the basis of the tetrapeptide Glm-Asn-Cys(Bzl)-Pro and other homologous fragments of neurohypophyseal hormones as common initial and intermediate compounds.The free dithiols obtained by the reduction of protected derivatives of (I)-(III) by sodium in liquid ammonia have been oxidized to the corresponding cyclic disulfides (I)-(III) with the aid of 1 M H2O2 at 0-5 deg C and pH (8.5.The vasopressor activities of (I)-(III) a re, respectively 470 +/- 20, 1.7, and 0.5 IU/mg (rat, in vivo).
