1300031-68-8

Basic information

• Product Name: 7-Iodo-6-Methoxy-4-quinolinol
• Synonyms: 7-Iodo-6-Methoxy-4-quinolinol;7-Iodo-6-Methoxyquinoline-4-ol;7-iodo-6-methoxy-4aH-quinolin-4-one;7-Iodo-6-methoxy-4-oxo-quinoline
• CAS NO: 1300031-68-8
• Molecular Formula: C₁₀H₈INO₂
• Molecular Weight: 301.08049
• EINECS: -0
• Mol File: 1300031-68-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 427.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.866
• PKA: 3.98±0.40(Predicted)
• CAS DataBase Reference: 7-Iodo-6-Methoxy-4-quinolinol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Iodo-6-Methoxy-4-quinolinol(1300031-68-8)
• EPA Substance Registry System: 7-Iodo-6-Methoxy-4-quinolinol(1300031-68-8)

Safety Data

• Hazardous Substances Data: 1300031-68-8(Hazardous Substances Data)

Usage

General Description

7-Iodo-6-methoxy-4-quinolinol is a chemical compound with the molecular formula C10H8INO2. It is a derivative of quinoline, a heterocyclic aromatic organic compound. The presence of the iodo and methoxy groups in the molecule gives it unique properties and potential applications in organic synthesis and medicinal chemistry. The compound is used in the development of pharmaceuticals and agrochemicals for its ability to act as a chelating agent and to form complexes with various metal ions. Additionally, the compound has been studied for its potential antimicrobial and antiviral properties. Overall, 7-Iodo-6-methoxy-4-quinolinol is a versatile chemical with promising applications in the fields of medicine and agriculture.

Upstream product

• 5399-03-1 2-iodo-1-methoxy-4-nitrobenzene 
• 1300031-69-9 5-{[(3-iodo-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 74587-12-5 3-iodo-4-methoxyaniline 

Downstream Products

• 1300031-50-8 7-(3,5-dimethyl-4-isoxazolyl)-8-(methoxy)-1-[(1R)-1-phenylethyl]-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinoline 
• 1300031-65-5 4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline 
• 1300031-63-3 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N⁴-((R)-1-phenylethyl)quinoline-3,4-diamine 
• 1300031-64-4 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-3-nitro-N-((R)-1-phenylethyl)quinolin-4-amine 

Relevant articles and documents

Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype

The bromodomain and extraterminal domain (BET) family of epigenetic regulators comprises four proteins (BRD2, BRD3, BRD4, BRDT), each containing tandem bromodomains. To date, small molecule inhibitors of these proteins typically bind all eight bromodomains of the family with similar affinity, resulting in a diverse range of biological effects. To enable further understanding of the broad phenotype characteristic of pan-BET inhibition, the development of inhibitors selective for individual, or sets of, bromodomains within the family is required. In this regard, we report the discovery of a potent probe molecule possessing up to 150-fold selectivity for the N-terminal bromodomains (BD1s) over the C-terminal bromodomains (BD2s) of the BETs. Guided by structural information, a specific amino acid difference between BD1 and BD2 domains was targeted for selective interaction with chemical functionality appended to the previously developed I-BET151 scaffold. Data presented herein demonstrate that selective inhibition of BD1 domains is sufficient to drive anti-inflammatory and antiproliferative effects.

Imidazo [4, 5-C] Quinoline Derivatives As Bromodomain Inhibitors

Novel compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.