1300049-18-6

Basic information

• Product Name: KNI-10776
• CAS NO: 1300049-18-6
• Molecular Weight: 773.006
• Mol File: 1300049-18-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: KNI-10776(CAS DataBase Reference)
• NIST Chemistry Reference: KNI-10776(1300049-18-6)
• EPA Substance Registry System: KNI-10776(1300049-18-6)

Safety Data

• Hazardous Substances Data: 1300049-18-6(Hazardous Substances Data)

Upstream product

• 117918-23-7 (R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid 
• 62023-65-8 (2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 5813-64-9 2.2-dimethylpropylamine 
• 20859-02-3 L-tert-Leucine 
• 1061338-75-7 (R)-N-(2,2-dimethylpropyl)-3-{(2S,3S)-3-[(2S)-2-amino-3,3-dimethylbutanoylamino]-2-hydroxy-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 
• 25774-02-1 monobenzyl phenylmalonate 
• 1061338-63-3 (R)-N-(2,2-dimethylpropyl)-3-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 
• 1061338-51-9 (R)-N-(2,2-dimethylpropyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxamide 

Relevant articles and documents

Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors

The human T cell lymphotropic/leukemia virus type 1 (HTLV-I) causes adult T cell lymphoma/leukemia. The virus is also responsible for chronic progressive myelopathy and several inflammatory diseases. To stop the manufacturing of new viral components, in our previous reports, we derived small tetrapeptidic HTLV-I protease inhibitors with an important amide-capping moiety at the P3 residue. In the current study, we removed the P3-cap moiety and, with great difficulty, optimized the P3 residue for HTLV-I protease inhibition potency. We discovered a very potent and small tetrapeptidic HTLV-I protease inhibitor (KNI-10774a, IC50 = 13 nM).