130013-83-1

Basic information

• Product Name: Boc-L-Ala-nitrile
• Synonyms: (S)-N-BOC-ALANINE-NITRILE;N-[(1S)-1-Cyanoethyl]-carbamic acid 1,1-dimethylethyl ester;BOC-L-ALA-NITRILE;Boc-Ala-Nitrile;Carbamic acid, [(1S)-1-cyanoethyl]-, 1,1-dimethylethyl ester (9CI);(S)-tert-butyl 1-cyanoethylcarbamate;Boc-L-Ala-Nitrile Or (S)-Tert-Butyl1-CyanoethylcarbaMate;tert-butyl N-[(1S)-1-cyanoethyl]carbaMate
• CAS NO: 130013-83-1
• Molecular Formula: C8H14N2O2
• Molecular Weight: 170.21
• Product Categories: N-BOC
• Mol File: 130013-83-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 105-108°C
• Boiling Point: 277°C
• Flash Point: 121°C
• Appearance: White to off-white powder
• Density: 1.021
• CAS DataBase Reference: Boc-L-Ala-nitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Ala-nitrile(130013-83-1)
• EPA Substance Registry System: Boc-L-Ala-nitrile(130013-83-1)

Safety Data

• Hazardous Substances Data: 130013-83-1(Hazardous Substances Data)

Usage

General Description

Boc-L-Ala-nitrile is a chemical compound used primarily as a building block in peptide synthesis, the process of creating peptides, which are compounds consisting of two or more amino acids. The 'Boc' in Boc-L-Ala-nitrile is an abbreviation for tert-butyloxycarbonyl, a protective group used in the production of peptides. The 'L-Ala' denotes the L form of the amino acid alanine. Nitrile indicates the presence of a specific functional group consisting of a carbon atom triple-bonded to a nitrogen atom. This chemical is particularly important in biochemistry and pharmaceutical industries.

Upstream product

• 79069-50-4 Boc-Ala-H 
• 15761-38-3 L-N-Boc-Ala 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 365441-85-6 N-(tert-butoxycarbonyl)-1-tosyleth-1-ylamine 
• 78981-25-6 tert-butyl (1S)-2-amino-1-methyl-2-oxoethylcarbamate 

Downstream Products

• 96929-01-0 N-(tert-Butyloxycarbonyl)-DL-thioalaninamid 

Relevant articles and documents

Structural revision of halipeptins: Synthesis of the thiazoline unit and isolation of halipeptin C

The structural revision of the anti-inflammatory marine metabolites halipeptin A (1) and B (2) along with the isolation of the new related product halipeptin C (3) are reported. In particular, the heterocyclic portion of the molecule, incorrectly assigned as an oxazetidine ring, has now been characterised as a thiazoline unit by comparison of the spectral data of the natural products (1-3) with an appropriate synthetic model (10). GIAO calculated 13C NMR chemical shifts for oxazetidine and thiazoline model compounds provide additional support to the revised structure.

1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS

The present invention relates to 1,2,4-oxadiazole compounds of formula (I) and their use to inhibit the programmed cell death (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1,PD-L1 or PD-L2.

Total syntheses of bacillamide C and neobacillamide A; Revision of their absolute configurations

The enantiospecific syntheses of both enantiomers of bacillamide C and neobacillamide A are described, along with the measurement of their optical activities, leading to the revision of the proposed absolute configurations of these natural products.