130016-69-2Relevant academic research and scientific papers
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives
Wang, Guangyi,Lei, Huoxing,Wang, Xiaofang,Das, Debasis,Hong, Jian,Mackinnon, Colin H.,Coulter, Thomas S.,Montalbetti, Christian A.G.N.,Mears, Richard,Gai, Xinjie,Bailey, Sarah E.,Ruhrmund, Donald,Hooi, Lisa,Misialek, Shawn,Rajagopalan, P.T. Ravi,Cheng, Robert K.Y.,Barker, John J.,Felicetti, Brunella,Schoenfeld, Dorian L.,Stoycheva, Antitsa,Buckman, Brad O.,Kossen, Karl,Seiwert, Scott D.,Beigelman, Leonid
scheme or table, p. 4480 - 4483 (2010/04/05)
(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Novel Inhibitors of Hepatitis C Virus Replication
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Page/Page column 60-61, (2009/10/21)
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
THE ALKYLATION OF METHYL 2-(1-PYRROLYL)ACETATE. A NEW SYNTHETIC METHOD OF α-AMINO ACIDS
Kashima, Choji,Maruyama, Tatsuya
, p. 1727 - 1730 (2007/10/02)
The alkylation of 2-(1-pyrrolyl)acetates was accomplished by the treatment with alkyl halides in the presence of LDA to give 2-(1-pyrrolyl)alkanoates, which were convertible into α-amino acids by ozonolysis.
